RNA is a highly versatile molecule and exhibits many diverse functions. Our lab explores new approaches and chemical tools to target RNA in bacteria. >Our interests lie at the intersection of nucleic acid chemistry and antimicrobial research.

Synthesizing customized affinity-based profiling tools we study RNA structural folding and small molecule ligand binding to bacterial RNAs to explore these as antibacterial targets. We can determine ligand binding sites with single nucleotide resolution. Taking advantage of the unusual nucleophilicity of the 2'-OH position of RNA we are working on a conceptual new approach to covalently target RNA.

We explore new possibilities for antibacterial antisense therapies. Using synthetic versions of endogenous iron-binders known as siderophores, we can effectively transport large antisense oligomers into bacteria and selectively down regulate protein production of essential genes. With this method we can produce potent ‘asobiotics’.